3001Analgesia with nitrous oxide/oxygen and acetaminophen compared to morphine analgesia in patients with acute myocardial infarction: results from the SCADOL II clinical trial

Abstract

Background: The safety of morphine use has been questioned in the management of ST Elevation Myocardial Infarction (STEMI). Are there other analgesics that are at least as effective without adverse effects? Purpose: Evaluate the non-inferiority of nitrous oxide/oxygen plus acetaminophen versus morphine in pre-hospital patients with STEMI. Method(s): Multi-center, randomized, non-inferiority cluster study. Thirty-eight mobile intensive care unit centres were randomized. Inclusion criteria: patients with STEMI and pain intensity score >= 4 on the numerical rating scale (NRS). Outcome(s): proportion of patient with NRS