The roles of CCR7 for the homing of memory cd8+ t cells into their survival niches

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Abstract

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functionsIn this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.

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Choi, H., Song, H., & Jung, Y. W. (2020). The roles of CCR7 for the homing of memory cd8+ t cells into their survival niches. Immune Network, 20(3), 1–15. https://doi.org/10.4110/in.2020.20.e20

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