Lateral tension-induced penetration of particles into a liposome

5Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

It is important that we understand the mechanism of the penetration of particles into a living cell to achieve advances in bionanotechnology, such as for treatment, visualization within a cell, and genetic modification. Although there have been many studies on the application of functional particles to cells, the basic mechanism of penetration across a biological membrane is still poorly understood. Here we used a model membrane system to demonstrate that lateral membrane tension drives particle penetration across a lipid bilayer. After the application of osmotic pressure, fully wrapped particles on a liposome surface were found to enter the liposome. We discuss the mechanism of the tension-induced penetration in terms of narrow constriction of the membrane at the neck part. The present findings are expected to provide insight into the application of particles to biological systems.

Cite

CITATION STYLE

APA

Shigyou, K., Nagai, K. H., & Hamada, T. (2017). Lateral tension-induced penetration of particles into a liposome. Materials, 10(7). https://doi.org/10.3390/ma10070765

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free