Investigation of antimicrobial, antioxidant, and DNA binding studies of bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

Abstract

A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]·nH2O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 1-4 possess square planar geometry. Antimicrobial activities of HL and complexes 1-4 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger). These results show that complexes 1-4 have good antimicrobial activity compared to HL. The DNA cleavage activity of HL and complexes 1-4 was monitored by the agarose gel electrophoresis method. The antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. DNA binding properties of HL and complexes 1-4 have been investigated by electronic absorption technique and viscometric measurements.