ALYREF links 3′‐end processing to nuclear export of non‐polyadenylated mRNA s

Abstract

Synopsis The RNA-binding protein ALYREF functions in coupling nuclear export and 3'-end processing of polyadenylated mRNAs. New data identify a parallel mechanism for ALYREF also linking 3'-end processing to nuclear export of non-polyadenylated, replication-dependent histone mRNAs. ALYREF prevalently binds to a 3' region of histone mRNAs in an SLBP-dependent manner. ALYREF promotes histone pre-mRNA processing by ensuring U7-snRNP recruitment. The TREX complex facilitates histone mRNA export by recruiting NXF1. 3'-end processing promotes ALYREF recruitment and histone mRNA export.