Comparative skeletal muscle aging

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Abstract

The decline in skeletal muscle function is characteristic of aging organisms across species ranging from C elegans to humans. This is a multifaceted process involving changes in both the quantity (sarcopenia) and quality of skeletal muscle with age. This chapter describes age-related changes in several aspects of muscle function, including energy metabolism, muscle contraction, stem cell and injury repair and response to cellular stress. We pay particular attention to the effect of aging on different muscle fiber types. These fiber type differences, which are often overlooked, may explain some of the apparent contradictory results in the literature. © 2010 Springer Science+Business Media B.V.

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Marcinek, D. J., Wanagat, J., & Villarin, J. J. (2010). Comparative skeletal muscle aging. In The Comparative Biology of Aging (pp. 287–317). Springer Netherlands. https://doi.org/10.1007/978-90-481-3465-6_13

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