Asymmetric opening of the epoxide ring in cyclohexene oxide by thiophenol using homochiral phosphinamide catalysts

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Abstract

Enantiomerically pure phosphinamides containing a pendant hydroxyl group catalyse the Al(III)-promoted ring opening of the meso epoxide in cyclohexene oxide with thiophenol in up to 80% enantiomeric excess.

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Nagasawa, A., Lin, C., & Wills, M. (2007). Asymmetric opening of the epoxide ring in cyclohexene oxide by thiophenol using homochiral phosphinamide catalysts. Journal of Chemical Research, (1), 1–4. https://doi.org/10.3184/030823407780199595

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