Background: Adipocytes are known to metabolize but not synthesize de novo steroids or oxysterols. Results: CYP11A1 in adipocytes is able to synthesize pregnenolone; 27-hydroxycholesterol (27HC) is a major cholesterol metabolite in adipocytes exhibiting anti-adipogenic activity. Conclusion: Adipocytes have the ability to synthesize steroids and oxysterols de novo. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
CITATION STYLE
Li, J., Daly, E., Campioli, E., Wabitsch, M., & Papadopoulos, V. (2014). De novo synthesis of steroids and oxysterols in adipocytes. Journal of Biological Chemistry, 289(2), 747–764. https://doi.org/10.1074/jbc.M113.534172
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