Fredericamycin A, A New Antitumor Antibiotic I. Production, Isolation and Physicochemical Properties

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Abstract

A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described. © 1981, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Pandey, R. C., Toussaint, M. W., Stroshane, R. M., Kalita, C. C., Aszalos, A. A., Garretson, A. L., … White, R. J. (1981). Fredericamycin A, A New Antitumor Antibiotic I. Production, Isolation and Physicochemical Properties. Journal of Antibiotics, 34(11), 1389–1401. https://doi.org/10.7164/antibiotics.34.1389

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