The impact of long-term moderate level of vaccination coverage for epidemiology of varicella in Lu'an, China: Should we change immunization strategy now?

Abstract

As China implements the voluntary vaccination program of one-dose of varicella vaccine for decades, robust estimates of the impact of voluntary vaccination era on epidemiology of varicella are needed. We estimated the vaccination coverage (VC) of varicella vaccine (VarV) by using surveillance data on immunization. The descriptive epidemiological method was used to describe the changing epidemiology of varicella from 2007 to 2018. The screening method was used to estimate the vaccine effectiveness (VE) of VarV. The overall VC for VarV was 71.7%, ranged from 47.7% to 79.5% among 2008-2017 birth cohorts. In total, 16,660 varicella cases were reported during 2007-2018, the incidence increased from 10.0 cases per 100000 population in 2007 to 65.2 cases per 100000 population in 2018. A shift in age group of varicella was observed since 2012, with the age increased from 5-9 years to10-14 years. The overall VE was 79.9%, and the VE increased from 60.1% in 2008 birth cohort to 96.2% in 2017 birth cohort. We found that the overall VE for VarV is moderate, but appears highly effective within 5 years after vaccination. In addition, a shift varicella infection to older ages has occurred at long-term moderate level VC of one-dose VarV. Therefore, to contain the incidence of varicella and prevent any potential shift to older ages, the introduction of VarV into routine immunization program is likely needed in Lu'an.