Accelerated decline in lung function in smoking women with airways obstruction: SAPALDIA 2 cohort study

52Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: The aim was to determine if effects from smoking on lung function measured over 11 years differ between men and women. Methods: In a prospective population based cohort study (Swiss Study on Air Pollution and Lung Diseases in Adults) current smokers in 1991 (18 - 60 yrs) were reassessed in 2002 (n=1792). Multiple linear regression was used to estimate effects from pack-years of cigarettes smoked to 1991 and mean packs of cigarettes smoked per day between 1991 and 2002 on change in lung volume and flows over the 11 years. Results: In both sexes, packs smoked between assessments were related to lung function decline but pack-years smoked before 1991 were not. Mean annual decline in FEV1 was - 10.4 mL(95%CI - 15.3, -5.5) per pack per day between assessments in men and -13.8 mL(95%CI-19.5,-8.1) in women. Decline per pack per day between 1991 and 2002 was lower in women who smoked in 1991 but quit before 2002 compared to persistent smokers (-6.4 vs -11.6mL, p=0.05) but this was not seen in men (-14.3 vs -8.8 mL p=0.49). Smoking related decline was accelerated in men and women with airway obstruction, particularly in women where decline in FEV1 was three fold higher in participants with FEV1/FVC<0.70 compared to other women (-39.4 vs -12.2 mL/yr per pack per day, p<0.002). Conclusions: There are differences in effects from smoking on lung function between men and women. Lung function recovers faster in women quitters than in men. Women current smokers with airway obstruction experience a greater smoking related decline in lung function than men. © 2005 Downs et al., licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Downs, S. H., Brändli, O., Zellweger, J. P., Schindler, C., Künzli, N., Gerbase, M. W., … Ackermann-Liebrich, U. (2005). Accelerated decline in lung function in smoking women with airways obstruction: SAPALDIA 2 cohort study. Respiratory Research, 6. https://doi.org/10.1186/1465-9921-6-45

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free