Rapid progression of a growth hormone producing tumour during dopamine agonist treatment

Abstract

Treatment with dopamine agonists has been tried in patients with growth hormone producing tumours and acromegaly. Most reports show that the concentrations of growth hormone decrease in most patients with acromegaly,1but some claim that concentrations decrease only in patients who have shown a modest increase in growth hormone concentrations.2 According to other authors, dopamine agonists are effective only in patients with acromegaly and hyperprolactinaemia.3 We report on a Patient with acromegaly and hyperprolactinaemia, in whom treatment with the dopamine agonist bromocriptine caused a rapid progression of the growth hormone producing tumour. © 1987, British Medical Journal Publishing Group. All rights reserved.