New Resorcinol Derivatives: Preparation, Characterization and Theoretical Investigation

Abstract

Our interest in this area has been to employ synthesis organic methods to prepare anew resorcinol derivatives with high yield present. The precursor material have been used to prepare di-substituted molecule pharmaceutical compounds by reacting with acetic acid and zinc dichloride as catalyst at first time. At second time reaction the product with chloro acetic acid using the Sodium hydroxide to converting the carboxyl group in the last product to an acid chloride by SOCl2. The acid chloride then dissolved in DCM and react with four different amino drugs (Sulfadiazine, Theophyllne, Paracetamole and 4-amino antipyrineto produce the new preparative compounds. All the prepared compounds were characterized by FT-1R,1-HNMR and 13CNMR. The physical different solvents. Theoretical investigation is done to provethe nature of acylation reaction of resorcinol through suggestion three different transition states. Three suggested transition states are examined for the most probable pathway of the acylation reaction. The calculation prove that the acylation reaction is done through the para position of aromatic ring with high yield present than other positions.