Morphology and the natural history of cribriform adenocarcinoma (adenoid cystic carcinoma)

Abstract

Cribriform adenocarcinoma (adenoid cystic carcinoma) of mixed glandular origin was the diagnosis in 45 surgical specimens in the Institute mentioned. Structural studies emphasise the classical cribriform pattern (cylindroma) which indicates the capacity of this neoplasm to behave as both an epithelial and a connective tissue type tumor. In terms of survival, it does not appear to be as malignant as other forms of carcinoma arising in similar anatomic locations. The 5 yr crude survival rate (56%) compares favorably with that of other carcinomas of the palate and paranasal sinuses. A recurrent rate of the order of 20% may persist up to 10 yr after primary treatment, and while this is not inimical to longer survival there is clearly a high morbidity.