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GMP and AMP as methyl radical traps in the reaction with pentaamminemethylcobalt(III)

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Abstract

C8 methylation of the title purine nucleotides was achieved in near neutral aqueous solution by reaction with 13C enriched [Co(NH 3) 5(CH 3)] 2+. This cation decomposes upon dissolution in water by release of a methyl radical. The latter was identified by electron spin resonance (ESR) spectroscopy as the PBN/13ĊH3 adduct (PBN = phenyl-N-tert-butylnitrone). When the purine nucleotide was used in large excess, the efficiency of the trapping by the C8 atom was determined by integration of the 13C NMR signals to be 20-25% for GMP and 15-20% for AMP, respectively, at 37°C. © 2004 Elsevier Inc. All rights reserved.

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Kofod, P. (2004). GMP and AMP as methyl radical traps in the reaction with pentaamminemethylcobalt(III). Journal of Inorganic Biochemistry, 98(11), 1978–1980. https://doi.org/10.1016/j.jinorgbio.2004.08.014

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