Synthesis of stilbene derivatives: A comparative study of their antioxidant activities

Abstract

A series of structurally simple compounds belonging to thestilbene family were synthesized by means of a Ti(III).mediated methodology that allows access, in an efficient manner, to derivatives of dihydrostilbene, E-stilbene, and stilbene oxide, with high yields. The antioxidant activity of these compounds has been evaluated by means of two electrochemical assays, which provide complementary information, showing that the majority of these stilbene analogs exhibit significant antioxidant activity dependent on the electronic structure and functionalization of the molecule in each case.