Potential Antidiabetic Properties of Syzygium Cumini (L.) Skeels Leaf Extract-Mediated Silver Nanoparticles

Abstract

This study explores the use of Syzygium cumini (L.) Skeels plant aqueous leaf extract as a reducing agent, which enables the green synthesis and comprehensive characterization of silver nanoparticles (AgNPs). The results indicated that the synthesized AgNPs were spherical in shape with an average size of 27.5 nm and a silver content of approximately 43.18%. The AgNPs exhibited promising antidiabetic and wound-healing properties. The antidiabetic activity, measured through glucose uptake and α-amylase inhibition assays, showed values of 80.08% and 83.91%, respectively. Additionally, the cytotoxicity assessment revealed that the AgNPs exhibited good biocompatibility even at higher doses, indicating their lower toxicity profile. Furthermore, the AgNPs demonstrated wound-closure percentages of 27.59% and 92.48% at 12 h and 24 h respectively, post-treatment, indicating that they were as effective as that of the standard ascorbic acid. These findings suggest that Syzygium cumini-mediated AgNPs have significant potential for applications in antidiabetic and wound-healing treatments.