Summary: DNA vector-based short hairpin RNA (shRNA) as a means of effecting RNA interference (RNAi) is a promising mechanism for the precise disruption of gene expression to achieve a therapeutic effect. The clinical usage of shRNA therapeutics in cancer is limited by obstacles related to effective delivery into the nuclei of target cancer cells. Significant pre-clinical data have been amassed about biodegradable and non-biodegradable polymeric delivery vehicles that are relevant for shRNA delivery into humans. Here, we will review some leading candidates for clinical usage with a focus on studies relating to their potential for usage in cancer shRNA therapeutics and discuss some of the advantages and disadvantages of using biodegradable and non-biodegradable delivery vehicles. © 2009 Humana Press.
CITATION STYLE
Vorhies, J. S., & Nemunaitis, J. J. (2009). Synthetic vs. natural/biodegradable polymers for delivery of shRNA-based Cancer Therapies. Methods in Molecular Biology, 480, 11–29. https://doi.org/10.1007/978-1-59745-429-2_2
Mendeley helps you to discover research relevant for your work.