Spectroscopic and computational investigation of actinium coordination chemistry

Abstract

Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac III reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-O H 2 O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac III and Am III in HCl solutions indicate Ac III coordinates more inner-sphere Cl 1-ligands (3.2±1.1) than Am III (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac III chemical behaviour.