Cytotoxic Potential of Andrographolide against Bovine Tuberculosis

Abstract

Bovine tuberculosis is a chronic mycobacterial infection that impinges on a wide range of mammals, including man, cattle, deer, pigs and carnivores. The present investigation deals with the anti-mycobacterial potential of Andrographolide against Mycobacterium bovis, commonly known as bovine tuberculosis.The bioactive compound andrographolide was isolated from the leaves of Andrographis paniculata. Employing different techniques viz. zone of inhibition, disc diffusion and turbidometric method, the MIC of andrographolide was found to be vacillating between 100 and 11.11µg/ml against the test organism (Garg & Shrivastava, 2013). The results suggested andrographolide compound to be a potent antibiotic against M. bovis and its inhibitory effect is on par with standard drugs like isoniazid and fluoroquinolones.