Solid‐state nmr spectroscopy: A key tool to unravel the supramolecular structure of drug delivery systems

Abstract

In the past decades, nanosized drug delivery systems (DDS) have been extensively devel-oped and studied as a promising way to improve the performance of a drug and reduce its unde-sirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid‐state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.