S121 The occupations at increased copd risk in the large population-based uk biobank cohort

Abstract

Background Occupational exposures are important and preventable causes of COPD. In a cross-sectional study of current occupation among over 220,000 workers in the UK Biobank cohort (over 500,000 subjects) we previously reported that 14 jobs were associated with increased COPD risk (De Matteis S, et al., OEM, 2016). To progress these findings we developed OSCAR, a new web-based tool for efficient self-reporting and automatic coding of job-histories in large population-based studies. Our aim was to identify the occupations at increased COPD risk taking into account lifetime job-histories in the UK general population. Methods We administered OSCAR to all UK Biobank participants with an available email address (n= 324,653) between June-February 2016. Paid jobs held for at least six months were collected and coded by OSCAR using the UK Standard Occupational Classification (SOC), v.2000. COPD was defined as FEV1/FVC