Toll-like receptors in lupus nephritis

60Citations
Citations of this article
72Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity. However, data accumulating over the last decade imply an important role also for numerous elements of innate immunity, namely the Toll-like receptors in the pathogenesis of SLE. Here we discuss their role in the most common organ complication of SLE, i.e. lupus nephritis. We summarize experimental and clinical data on the expression and functional contribution of the Toll-like receptors in immune complex glomerulonephritis, and intrarenal inflammation. Based on these discoveries Toll-like receptors are evolving as therapeutic targets for the treatment of SLE and lupus nephritis.

Cite

CITATION STYLE

APA

Devarapu, S. K., & Anders, H. J. (2018, April 12). Toll-like receptors in lupus nephritis. Journal of Biomedical Science. BioMed Central Ltd. https://doi.org/10.1186/s12929-018-0436-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free