Structural characterization of transferrin-bound ruthenium(II) terpyridine complexes

  • Matijević M
  • Cindrić M
  • Petković M
  • et al.
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Abstract

Cardiovascular disease (CVD) and preeclampsia share several common metabolic and structural abnormalities such as, lipid abnormalities, oxidative stress, and inflammatory response and acute atherosis of the placental bed and atherosclerotic plaque. Further, there is an increased neutrophil activation with elevated C-reactive protein levels and an increased leukocyte adhesion to endothelium may be the other contributor of the preeclampsia. The similarity between the pathogenesis of preeclampsia and the atherosclerosis has led researchers to investigate the role of Lp(a) in pre-eclampsia because of its act as an acute phase protein and plays a role as a vehicle for cholesterol deposition at the site of abnormal placentation. It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. Further, LPA genotypes which carry high CVD risk are not evaluated along with cardiovascular risk. Our study tested whether cardiovascular corresponding LPA risk genotypes improve preeclampsia and cardiovascular disease (CVD) risk prediction beyond conventional risk factors. We were included 200 pregnant Turkish women into the study. We stratified the preeclamptic (PE) group: early (EOP) (28.7 +/- 3.0 weeks) and late onset(LOP) (36.0 +/- 1.4 weeks). 14 LPA SNPs were evaluated in the study. rs9355296 and rs3798220 were found an independent risk factor for preeclampsia by logistic regression analysis. A positive correlation was found between rs9355296 and the diagnostic criteria of preeclampsia. Further rs9355296 G/* carriers have higher vascular inflammation rather than AA carriers. The findings reveal that LPA genetic variability with high inflammatory response might be an indication of future cardiovascular events.

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Matijević, M., Cindrić, M., Petković, M., & Nišavić, M. (2018). Structural characterization of transferrin-bound ruthenium(II) terpyridine complexes. Febs Open Bio, 8(1), 406+. https://doi.org/10.1002/2211-5463.12453

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