BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state associated with reversible cerebral vaso-genic edema. It is an increasingly recognized occurrence in the oncology population. However, it is very uncommon in patients with primary brain tumors (PBT). The aim of this study isto analyze the clinical manifestations, radiological features and report clinical outcomes of PRES in PBT patients. METHOD(S): In this retrospective review, we identified 4 patients with PBTs who developed PRES at MDACC between 2012 and 2014. Clinical and radiographic datawere abstracted from their records. In addition, we also solicited 2 cases from the literature. RESULT(S): The median age at diagnosis of PRES was 47 years (range 5-62), the male: female ratio was 1:5 and occurred in patients with glioblastoma (N = 3), diffuse intrinsic pontine glioma (N = 1), anaplas-tic ependymoma (N = 1) and atypical meningioma (N = 1). The two cases from literature review had received bevacizumab, and only one case received chemotherapy (cisplatin/etoposide/temozolomide) before the symptoms onset. Clinical presentation included seizures (N = 3), altered mental status (N = 3), headache (N = 2) and focal neurologic deficits(N = 2). All of the patients presented with elevated blood pressure. Three patients had atypical imaging findings, one of them also developed infarctions in those areas. Three of our MDACC patients recovered completely in 3 to 4 weeks after the symptoms onset. One patient died due to active cancer and several comor-bidities including PRES. CONCLUSION(S): HTN seems to be the most important co-existent risk factor for development of PRES. The clinical and radiological course of PRES in PBT patients did not vary from the classical descriptions of PRES found inother causes. Resolution of PRES was an indepen-dent process even to that of tumor progression. PRES distribution did not correlate with the brain tumor location. Delay in diagnosis can resultin perma-nent residual deficits.
Mendeley helps you to discover research relevant for your work.
CITATION STYLE
Kamiya-Matsuoka, C., Cachia, D., Armstrong, T., & Gilbert, M. (2014). CN-09 * POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME AND PRIMARY BRAIN TUMORS. Neuro-Oncology, 16(suppl 5), v47–v48. https://doi.org/10.1093/neuonc/nou243.9