131I-chTNT injection to relieve tracheal obstruction in advanced NSCLC patient

Abstract

OBJECTIVE: To relieve large airway obstruction in a patient with advanced non-small cell lung cancer (NSCLC) by injecting the mouse-human chimeric monoclonal antibody radiolabeled with iodine 131 chimeric tumor necrotic treatment (131I-chTNT) and to study the irradiation absorption in the tumor and critical organs. METHODS: A 50-year-old patient with NSCLC was treated with radioimmunotherapy. His airway was still obstructed in spite of intensive chemotherapy and radiotherapy. 131I-chTNT was injected into the tumor at the right bronchus through a fiberscope. A 131I scan was performed during treatment, and a computed tomography (CT) scan of the chest and fiberscope were performed pre- and post-treatment. 131I-chTNT distribution in tissues was followed for up to 4 weeks using gamma camera imaging. RESULTS: The radiation material accumulated notably in the tumor, relieving the patient's symptoms by suppressing the tumor. Recanalization of the airway was achieved so that the patient was able to breathe easily and cough. CONCLUSION: As a new type of radioimmunotherapy, 131I-chTNT may be helpful in treatment of advanced lung cancer.