Experimental properties of THPC based normoxic polyacrylamide gels for use in x-ray computed tomography gel dosimetry

Abstract

The aim of the present study is to investigate the effects of tetrakis(hydroxymethyl)phosphonium chloride (THPC) on the experimental properties of normoxic polyacrylamide gels. Specifically we: (1) assess the use of THPC as an anti-oxidant for x-ray CT PAGAT dosimetry by investigating dose response reproducibility and stability, and optimal THPC concentration for maximum dose sensitivity while ensuring no O2 inhibition; (2) investigate the reactions of THPC with gel constituents; (3) describe the reaction mechanisms of THPC in PAGAT polymer gels; (4) assess the effects of THPC on O2 diffusion through the polymer gel. © 2006 IOP Publishing Ltd.