Bone mineral density evolution after successful parathyroidectomy in patients with normocalcemic primary hyperparathyroidism

Abstract

Context: It is unclear whether bone mineral density (BMD) improves in patients with normocalcemic primary hyperparathyroidism (PHPT) after parathyroidectomy (PTX). Objective: The objective of the study was to evaluate and compare the impact of PTX on BMD change at 1 year in normocalcemic vs hypercalcemic PHPT. Design: This was a longitudinal cohort study. Setting: The study took place at a referral center. Patients: We included 60 PHPT patients (mean age 64.0 ± 10.1 years), successfully treated by PTX by the same surgeon. Two groups were individualized according to baseline serum total (albumin corrected) calcium: 39 patients with normal baseline serum total calcium (normocalcemic group) and 21 patients with hypercalcemia at baseline (hypercalcemic group). Main Outcome Measure: BMD changes 1 year after PTX were measured. Results: In the normocalcemic group, BMD increased significantly by +2.3 ± 5.0% at the spine (P = .016) and +1.9 ± 5.7% at the hip (P = .048). In the hypercalcemic group, BMD increased significantly by+4.0±3.8% at the spine (P=.0003) and+3.2±4.2% at the hip (P=.003). There was no difference in these BMD gains between both groups (P