Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory

Abstract

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3. h of sleep deprivation significantly impaired memory when deprivation began 1. h after training. In contrast, 3. h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1. h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4. h after training, during which sleep deprivation impairs hippocampal function. © 2013 Elsevier Inc.