A stoichiometric molecularly imprinted polymer for the class-selective recognition of antibiotics in aqueous media

Abstract

(Chemical Equation Presented) Making a good impression: A molecularly imprinted polymer is prepared against Penicillin G by using a stoichiometric quantity of a urea-based monomer. This polymer displays a high affinity for the template (see picture) and other β-lactam antibiotics, as determined by chromatographic retention factors in high quantities of buffer (90%). Retention values on the nonimprinted polymer were dramatically lower under the same conditions. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.