The Combination Treatment of Ultrasound and Antitumor Drugs on Yoshida Sarcoma

Abstract

The antitumor effect ultrasound (ULS) and/or antitumor drugs such as daunomycin (daunorubicin, DNR) and adriamycin (ADM) were determined in the rats bearing Yoshida sarcoma. The ULS transducer that was placedon the tumor was cooled to keep the temperature of the tissue within the nonthermal range. For the choice of the timing of the ILS irradiation after administration of the drug, the drug concentrations in the tumor and blood were determined and were analyzed pharmacokinetically. The drugs or ULS showed antitumor effect judged by the gowth of the tumor size or the survival time of the rat. The combination treatment of ULS and the drug marked an additional or synergistic effects on Yoshida sarcoma.