Expression of SSX genes in human tumors

N/ACitations
Citations of this article
40Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The HOM-MEL-40 antigen which is encoded by the SSX-2 gene was originally detected as a tumor antigen recognized by autologous IgG antibodies in a melanoma patient. Expression analysis demonstrated that SSX-2 is a member of the recently described cancer/testis antigen (CTA) class as it is expressed in a variety of different human neoplasms, but not in normal tissues with the exception of testis and a weak expression in the thyroid. Further studies demonstrated that SSX-2 belongs to a gene family consisting of at least 5 homologous genes. We now report the analysis of the expression of all 5 SSX genes in 325 specimens of human neoplasms from various histological origins, using reverse transcription polymerase chain reaction (RT-PCR). SSX-1, -2, and -4 were found to be expressed in 8%, 15% and 15%, of the tumors, respectively, while the expression of the SSX-5 gene was rare (71325), and SSX-3 expression was not detected. For defined tumor types, expression of at least one of the SSX family members was most frequently observed in head and neck cancer (75%), followed by ovarian cancer (50%), malignant melanoma (43%), lymphoma (36%), colorectal cancer (27%) and breast cancer (23%), while leukemias and the few cases of leiomyosarcomas, seminomas and thyroid cancers were found not to express any SSX gene.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Türeci, Ö., Chen, Y. T., Sahin, U., Güre, A. O., Zwick, C., Villena, C., … Pfreundschuh, M. (1998). Expression of SSX genes in human tumors. International Journal of Cancer, 77(1), 19–23. https://doi.org/10.1002/(SICI)1097-0215(19980703)77:1<19::AID-IJC4>3.0.CO;2-2

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

52%

Researcher 7

33%

Professor / Associate Prof. 3

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 10

45%

Agricultural and Biological Sciences 6

27%

Biochemistry, Genetics and Molecular Bi... 3

14%

Immunology and Microbiology 3

14%

Save time finding and organizing research with Mendeley

Sign up for free