Angiogenesis: Literature review

Abstract

Aim. The aim of this study was to examine theoretical aspects of angiogenesis. Methods. The analysis of current literature and studies devoted to angiogenesis process. Results. The healthy body controls angiogenesis through a balance of modulators, regulated by a strong interaction between growth factors and inhibitors, the imbalance of which can lead to disease. These diseases are caused by both excessive angiogenesis (cancer, diabetic eye disease, rheumatoid arthritis), and insufficient angiogenesis (coronary heart disease, stroke, delayed wound healing). Also some perspective treatment modalities for these patients are revealed. Conclusion. Over one billion people worldwide suffer from diseases associated with disturbed angiogenesis. Comprehensive study of angiogenesis provides better understanding of the formation of new vessels in the healthy body and of pathogenic mechanisms, which can help in prevention or treatment of some diseases.