Total synthesis of (±)-quadrangularin A

Abstract

The key to successful coupling in the synthesis of (±)- quadrangularin A (1) was the introduction of tert-butyl groups in the precursor to block two reactive positions. Thus, the oxidative coupling of 3,5-di-(tert-butyl) resveratrol was carried out regioselectively in an efficient total synthesis of the natural product. (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.