ProTide generated long-acting abacavir nanoformulations

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Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

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Lin, Z., Gautam, N., Alnouti, Y., McMillan, J., Bade, A. N., Gendelman, H. E., & Edagwa, B. (2018). ProTide generated long-acting abacavir nanoformulations. Chemical Communications, 54(60), 8371–8374. https://doi.org/10.1039/c8cc04708a

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