The association of a rare variant of-93,-53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance

Abstract

Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene-93 and-53 promoter gene n polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A substantial association was observed for-93 gene polymorphism of the LPL gene with obesity, while-53 promoter gene polymorphism showed association with IR. Conclusions: We found a significant association between-93 and-53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.