Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction

  • Sobirin M
  • Herry Y
  • Sofia S
  • et al.
N/ACitations
Citations of this article
52Readers
Mendeley users who have this article in their library.

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a leading cause of morbidity and mortality without an established treatment. Diastolic dysfunction, the hallmark of HFpEF, is associated with altered myocardial bioenergetics. No previous study has examined the effects of coenzyme Q10 (CoQ10) on left ventricle (LV) diastolic function in patients with HFpEF. We investigated whether CoQ10 could improve LV diastolic function in patients with HFpEF. We performed a randomized controlled trial (RCT) using pretest and posttest control groups of 30 patients with HFpEF. The patients received either CoQ10 100 mg three times a day or no CoQ10 in addition to routine treatment for 30 days. Echocardiographic study was performed at baseline and follow-up. LV diastolic function was evaluated by two dimensional and Doppler echocardiography as follows; average E/e׳, septal and lateral e׳velocity, and left atrium volume index (LAVI). A total of 28 patients completed the study. A statistically significant improvement was observed in the CoQ10 treatment group in terms between groups (∆E/e׳ ‒ 3.6 vs. ‒ 2.4; p = 0.28) and (∆LAVI ‒ 5.4 vs. ‒ 4.4; p = 0.83). Short term CoQ10 supplementation provided no additional benefits in improving LV diastolic function in patients with HFpEF.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Sobirin, M. A., Herry, Y., Sofia, S. N., Uddin, I., Rifqi, S., & Tsutsui, H. (2019). Effects of coenzyme Q10 supplementation on diastolic function in patients with heart failure with preserved ejection fraction. Drug Discoveries & Therapeutics, 13(1), 38–46. https://doi.org/10.5582/ddt.2019.01004

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 15

75%

Researcher 3

15%

Lecturer / Post doc 2

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 12

52%

Nursing and Health Professions 7

30%

Biochemistry, Genetics and Molecular Bi... 3

13%

Sports and Recreations 1

4%

Save time finding and organizing research with Mendeley

Sign up for free