Separate intramolecular targets for protein kinase A control N-Methyl-D-aspartate receptor gating and Ca2+ permeability

Abstract

Background: PKA increases NMDA receptor responses and phosphorylates multiple residues on C-terminal domains (CTD). Results: PKA inhibition reduced gating through GluN2B CTD and reduced Ca2+ permeability through GluN1 CTD. Conclusion: PKA controls NMDA receptor gating and Ca2+ permeability through distinct sites. Significance: Dissecting the complex modulatory effects of PKA on NMDAreceptors helps delineate fundamental mechanisms of synaptic regulation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.