The effect of a small polyphenolic and terpenoids phytochemical constituent on curing and preventing of Covid-19 infections

Abstract

Covid-19 spreading have caused millions of deaths worldwide and caused sever economic shrinking resulted in high levels of inflations. The on going pandemic has pushed the pharmaceutical companies to invent different vaccines to overcome the spreading of the virus and to reduce its effect on health and economy. Unfortunately, the middle and low income countries have been struggling in providing vaccines to their people due to the high expenses associated with vaccines ordering. Thus, the interest in finding a treatment and a prevention of Covid-19 from natural products has increased not in those countries only, even in high income countries. In this review we investigated the promising natural phytochemical compounds and their published mechanism of action in a prestigious peer-reviewed research journal throw different molecular docking and in vivo and vitro techniques. Its was found that the consumption of the medicinal plants containing small phenolic and terpenoids phytoconstituent like as thymoquinone, quercetin, caffeic acid, ursolic acid, ellagic acid, vanillin, and thymol have a great therapeutic effect for curing and preventing viral infections. This review has focused on the small polyphenolic and terpenoids compounds and their potential and mechanism activity against SARS-CoV-2. Our comprehensive analysis provides mechanistic insight into plant components for virus containment prevent infections and provide better solutions through natural therapeutically active ingredients.