Glycosides from Chinese Medicinal Plant, Hemsleya Panacis-Scandens, and Structure-Taste Relationship of Cucurbitane Glycosides

Abstract

From rhizomes pf Hemsleya panacis-scandens collected in Yunnan, China, eight new cucurbitane glycosides named scandenosides R1—R7 and dihydrocucurbitacin F glucoside (2-O-β-D-glucopyranoside of 23,24-dihydrocucurbitacin F) were isolated, along with six known cucurbitane glycosides. The structures of these new glycosides were determined on the basis of chemical and spectral data except for the configuration at C-20. Of these new glycosides, scandenoside R6 tastes sweet and R5 and dihydrocucurbitacin F glucoside taste bitter, while the others are tasteless. The structure-taste relationships of cucurbitane glycosides are discussed. © 1988, The Pharmaceutical Society of Japan. All rights reserved.