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Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro

Antimicrobial Agents and Chemotherapy (2017) 61(12)
DOI: 10.1128/AAC.01298-17
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Abstract

Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro. Synergy was found with a fractional inhibitory concentration index (FICI) score of ≤0.5 and a 4- to 10-fold decrease in MIC.

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CITATION STYLE

APA

Mukherjee, D., Wu, M. L., Teo, J. W. P., & Dick, T. (2017). Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro. Antimicrobial Agents and Chemotherapy, 61(12). https://doi.org/10.1128/AAC.01298-17

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