Global Trends in Research of NF- B in Melanoma from 2000 to 2021: A Study of Bibliometric Analysis

Abstract

In the pathogenesis of melanoma, NF-B is a key signaling pathway. Appling bibliometric analysis, we identify the frontiers and hotspots about NF-B in melanoma, as well as distinguishing features of scientific research and output all over the world during the past 22 years. 2226 publications published from 2000 to 2021 and related information were retrieved based on Science Citation Index Expanded (SCI-expanded) of Web of Science Core Collection (WoSCC). VOSviewer and Citespace were used to analyze bibliometric indicators and visualize the hotspots and research trend of studies on NF-B in melanoma. The results indicated that despite fluctuations, the number of publications (Np) related to the research of NF-B in melanoma per year increased over the past 22 years. The USA had the most publications. H-index and the number of citations (Nc) of the USA were also in the first place. PloS One was the most productive journal, and League of European Research Universities (LERU) was the most productive affiliation. Recently, the keywords "NF-kappa-b,""melanoma,""apoptosis,""expression,""activation,""cancer,"and "metastasis"appeared most frequently. Our study suggested that articles associated with NF-B in melanoma tend to increase. In this field, the USA was an influential country and a big producer. Most publications focused on clinical and basic research in the past 22 years, and keywords "tumor necrosis factor"and "trail induced apoptosis"had the highest burst strength.