Structural changes observed in mice liver due to chronic exposure of 1900-2200 mhz radiations emitted from mobile phone

Abstract

Background: Rapid developments in the telephone technology made the communication faster and easier. The duration of the use of mobile phones also increased beyond the limitation, and has raised public concerns about their safety. This study is designed to investigate the long term exposure of 1900 MHz to 2200 MHz radiations effect emitted from the third generation (3G) mobile phone in mice liver at histological and biochemical level. Materials and Methods: With approval from institutional animal ethics committee, 36 mice were exposed to 3G mobile phone radiation, 48 minutes per day for a period of 30 -180 days. The control group (36 mice) was kept under similar conditions without 3G exposure. The animals were sacrificed and the liver was removed from first month to six months period. 1ml of blood was collected for SGOT and SGPT analysis. Liver was processed for antioxidant enzyme activity – SOD & GPx, and for routine histological study. The serial sections were analysed under microscope for structural changes. Two groups’ data were compared and analysed statistically. Results: In comparision to control group the liver of 3G exposed groups showed the following changes: Parenchyma and the periportal regions were infiltrated with inflammatory cells. Focal haemorrhages in the liver parenchyma dilated and congested hepatic sinusoids. Swollen hepatocytes with pyknotic nuclei and vacuolations in the cytoplasm were the significant changes. Biochemical parameters did not show any variable difference. Conclusion: The long term exposure of ultra-high frequency radiation emitted from a 3G mobile phone could cause microscopic structural changes in the liver.