ACECLOFENAC LOADED SOLID LIPID NANOPARTICLES: OPTIMIZATION, IN VITRO AND EX-VIVO EVALUATION

Abstract

Objective: Rheumatoid arthritis is treated with aceclofenac as the first line of treatment. Aceclofenac is a BCS-II drug, when taken orally, causes first-pass metabolism and is partially water-insoluble causing some gastrointestinal (GI) issues. Objective of the work was preparation and evaluation of solid lipid nanoparticle for rheumatoid arthritis and increases the drug permeability and further possibility to decreasing the irritation. Methods: Different formulations batches were prepared by soya lecithin, tween 20, bees wax and cetyl alcohol lipid using lipid extrusion method. Further, the selected batch proceeded for Particle size, zeta potential, entrapment efficiency, in vitro release, Fourier transformed infrared (FTIR), X-ray diffraction studies (XRD), and ex-vivo study in goat skin. Results: As a result, selected batch have nanometric in size, 72.44% entrapment efficiency, and sustained drug released (71.33%) in 6 h. The Fourier transformed-infrared studies (FT-IR) and X-ray diffraction (XRD) study confirm the compatibility of the drug with excipients. Ex-vivo permeation study showed 74.85% in drug permeate in 6 h through goat skin. Conclusion: Research demonstrates that particle size and entrapment effectiveness are significantly influenced by the level of lipid and lecithin present. Additionally, it is suitable for the treatment of arthritis.