Recent progress in lysosomal α-mannosidase and its deficiency

30Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Lysosomal α-mannosidase (EC 3.2.1.24) is a major exoglycosidase in the glycoprotein degradation pathway. A deficiency of this enzyme causes the lysosomal storage disease, α-mannosidosis, which has been described in humans, cattle, domestic cats and guinea pigs. Recently, great progress has been made in studying the enzyme and its deficiency. This includes cloning of the gene encoding the enzyme, characterization of mutations related to the disease, establishment of valuable animal models, and encouraging results from bone marrow transplantation experiments.

Author supplied keywords

Cite

CITATION STYLE

APA

Sun, H., & Wolfe, J. H. (2001, March 31). Recent progress in lysosomal α-mannosidase and its deficiency. Experimental and Molecular Medicine. Korean Society of Med. Biochemistry and Mol. Biology. https://doi.org/10.1038/emm.2001.1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free