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Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains

Clinical and Vaccine Immunology (2013) 20(2) 302-305
DOI: 10.1128/CVI.00605-12
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Abstract

Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides. Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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APA

Yusim, K., Dilan, R., Borducchi, E., Stanley, K., Giorgi, E., Fischer, W., … Barouch, D. H. (2013). Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains. Clinical and Vaccine Immunology, 20(2), 302–305. https://doi.org/10.1128/CVI.00605-12

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