Abstract
Selection with modified aptamers: A method is described for design of glycocluster ligands by directed evolution. Glycan azides are attached to a library of alkyne-containing DNA sequences. DNA sequences which cluster the glycans best for multivalent binding to the target are selected and amplified. This method has been applied to the development of high-mannose clusters which bind HIV-neutralizing antibody 2G12. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MacPherson, I. S., Temme, J. S., Habeshian, S., Felczak, K., Pankiewicz, K., Hedstrom, L., & Krauss, I. J. (2011). Multivalent glycocluster design through directed evolution. Angewandte Chemie - International Edition, 50(47), 11238–11242. https://doi.org/10.1002/anie.201105555
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