The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43

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Abstract

Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology. Results: The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs. 1.7 in the control group (p=0.001); histology showed necrosis and inflammation in the knockout group. Conclusions: This research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.

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Trevisan, A. M., Cogliati, B., Homem, A. R., Aloiav, T. P. A., de Aquino Neto, N., Moreira, J. M., … D’Albuquerque, L. A. C. (2019). The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43. Acta Cirurgica Brasileira, 34(10). https://doi.org/10.1590/s0102-865020190100000003

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