Severe tooth wear in Prader-Willi syndrome. A case-control study

11Citations
Citations of this article
72Readers
Mendeley users who have this article in their library.

Abstract

Background: Prader-Willi syndrome (PWS) is a rare complex multsystemic genetic disorder characterized by severe neonatal hypotonia, endocrine disturbances, hyperphagia and obesity, mild mental retardation, learning disabilities, facial dysmorphology and oral abnormalities. The purpose of the present study was to explore the prevalence of tooth wear and possible risk factors in individuals with Prader-Willi syndrome.Methods: Forty-nine individuals (6-40 years) with PWS and an age- and sex-matched control group were included. Tooth wear was evaluated from dental casts and intraoral photographs and rated by four examiners using the Visual Erosion Dental Examination (VEDE) scoring system and the individual tooth wear index I A. In accordance with the VEDE scoring system, tooth wear was also evaluated clinically. Whole saliva was collected.Results: Mean VEDE score was 1.70 ± 1.44 in the PWS group and 0.46 ± 0.36 in the control group (p < 0.001). Median I A was 7.50 (2.60-30.70) in the PWS group and 2.60 (0.90-4.70) among controls (p < 0.001). In the PWS group tooth wear correlated significantly with age (VEDE; r = 0.79, p < 0.001, I A; r = 0.82, p < 0.001) and saliva secretion (VEDE; r = 0.46, p = 0.001, I A; r = 0.43, p = 0.002). Tooth grinding was also associated with tooth wear in the PWS group, as indicated by the mean VEDE 2.67 ± 1.62 in grinders and 1.14 ± 0.97 in non-grinders (p = 0.001) and median I A values 25.70 (5.48-68.55) in grinders and 5.70 (1.60-9.10) in non-grinders (p = 0.003). Multivariate linear regression analysis was performed with tooth wear as the dependent variable and PWS (yes/no), age, tooth grinding and saliva secretion as independent variables. PWS (yes/no), age and tooth grinding retained a significant association with tooth wear, VEDE (p < 0.001) and log I A (p < 0.001). The only factor significantly associated with tooth wear in the control group was age.Conclusions: Our study provides evidence that tooth wear, in terms of both erosion and attrition, is a severe problem in Prader-Willi syndrome. There is therefore considerable need for prosthodontic rehabilitation in young adults with PWS. © 2012 Saeves et al.; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Saeves, R., Espelid, I., Storhaug, K., Sandvik, L., & Nordgarden, H. (2012). Severe tooth wear in Prader-Willi syndrome. A case-control study. BMC Oral Health, 12(1). https://doi.org/10.1186/1472-6831-12-12

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free