Design, synthesis, and structure-activity relationship of novel CCR2 antagonists

Shankaran Kothandaraman; Karla L. Donnely; Gabor Butora; Richard Jiao; Alexander Pasternak; Gregori J. Morriello; Stephen D. Goble; Changyou Zhou; Sander G. Mills; Malcolm MacCoss; Pasquale P. Vicario; Julia M. Ayala; Julie A. DeMartino; Mary Struthers; Margaret A. Cascieri; Lihu Yang

Journal Article

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters (2009) 19(6) 1830-1834

DOI: 10.1016/j.bmcl.2008.12.050

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Abstract

A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity. © 2009.

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Kothandaraman, S., Donnely, K. L., Butora, G., Jiao, R., Pasternak, A., Morriello, G. J., … Yang, L. (2009). Design, synthesis, and structure-activity relationship of novel CCR2 antagonists. Bioorganic and Medicinal Chemistry Letters, 19(6), 1830–1834. https://doi.org/10.1016/j.bmcl.2008.12.050

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists

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